Allergic bronchopulmonary aspergillosis (ABPA)

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Introduction

ABPA is an important complication of asthma and cystic fibrosis resulting from hypersensitivity reaction to the fungus Aspergillus fumigatus.

a simple case introducing clincial presentation and calling for a differential diagnosis to get students thinking.

ABPA is characterized by intense airway inflammation with eosinophils and the formation of mucus plugs.

Neutrophils and deficiency of the anti-inflammatory cytokine IL-10 may be involved.

Periods of exacerbation and remission can lead to bronchiectasis and fibrotic lung disease.

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